Клетки Эпителия Бронхов Человека (HBEpC) предоставляют прекрасную модельную систему для изучения многих аспектов эпителиальных функций и заболеваний, особенно связанных с вирусными инфекциями дыхательных путей, механизмами восстановления тканей, сигнальными изменениями и потенциальными методами лечения травм легких, механического и оксидативного стресса, воспаления, легочных заболеваний и курения. При выращивании на вставках в среде раздела жидкость/воздух, HBEpC могут дифференцироваться в псевдостриарный эпителий и служить как более физиологическая трехмерная тканевая модель для исследований in vitro. HBEpC изображены здесь культивированными (L) и иммуномечеными на цитокератин (R). 
2016
Othumpangat, S., J. Noti, C. McMillen and D. Beezhold. 2016. ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection. Virology, 487:85-94.
Perez, D. and H. Chen. 2016. Methods and Compositions for in vivo Immune Stimulation and Antigen Production. Patent Application US 20160022807 A1.
2015
Burns, T., A. Ali, and D. Matesic. 2015. Comparative Effects of 4-Phenyl-3-Butenoic Acid and Vorinostat on Cell Growth and Signaling. Anticancer Research, 35: 775-784.
2014
Haselmayer, P., M. Camps, M. Muzerelle, S. El_bawab, C. Waltzinger, L. Bruns, N. Abla, M. Polokoff, C. Jond-necand, and M. Gaudet. 2014. Characterization of novel PI3Kδ inhibitors as potential therapeutics for SLE and lupus nephritis in pre-clinical studies. Name: Frontiers in Immunology. 5:233.
Nasreen, N., L. Gonzalves, S. Peruvemba, and K.A. Mohammed. 2014. Fluticasone furoate is more effective than mometasone furoate in restoring tobacco smoke inhibited SOCS-3 expression in airway epithelial cells. International Immunopharmacology. 19:153-160.
2012
Abdullah, L., C. Wolber, M. Kesimer, J. Sheehan, and C.W. Davis. 2012. Studying Mucin Secretion from Human Bronchial Epithelial Cell Primary Cultures. In Mucins. Vol. 842. M.A. McGuckin and D.J. Thornton, editors. Humana Press. 259-277.
Narisawa-Saito, M., Y. Inagawa, Y. Yoshimatsu, K. Haga, K. Tanaka, N. Egawa, S.-i. Ohno, H. Ichikawa, T. Yugawa, M. Fujita, and T. Kiyono. 2012. A critical role of MYC for transformation of human cells by HPV16 E6E7 and oncogenic HRAS. Carcinogenesis. 33:910-917.
Nasreen, N., N. Khodayari, B. Sukka-Ganesh, S. Peruvemba, and K.A. Mohammed. 2012. Fluticasone propionate and Salmeterol combination induces SOCS-3 expression in airway epithelial cells. International Immunopharmacology. 12:217-225.
Othumpangat, S., M. Regier, and G. Piedimonte. 2012a. Nerve growth factor modulates human rhinovirus infection in airway epithelial cells by controlling ICAM-1 expression. American Journal of Physiology. 302:L1057-L1066.
Othumpangat, S., C. Walton, and G. Piedimonte. 2012b. MicroRNA-221 Modulates RSV Replication in Human Bronchial Epithelium by Targeting NGF Expression. PloS one. 7:e30030.
2010
Berg, E.L., J. Yang, J. Melrose, D. Nguyen, S. Privat, E. Rosler, E.J. Kunkel, and S. Ekins. 2010. Chemical target and pathway toxicity mechanisms defined in primary human cell systems. Journal of Pharmacological and Toxicological Methods. 61:3-15.
Lung, J., K.-J. Liu, J.-Y. Chang, S.-J. Leu, and N.-Y. Shih. 2010. MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover. FEBS Journal. 277:4308-4321.
Maier, K.G., X. Han, B. Sadowitz, K.L. Gentile, F.A. Middleton, and V. Gahtan. 2010. Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia. Journal of Vascular Surgery. 51:1238-1247.
Mungunsukh, O., A.J. Griffin, Y.H. Lee, and R.M. Day. 2010. Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology. 298:L696-L703.
Tai, H.Y., M.F. Tam, H. Chou, D.W. Perng, and H.D. Shen. 2010. Pen ch 13 Major Fungal Allergen Decreases CD44 Expression in Human Bronchial Epithelial Cells. International Archives of Allergy and Immunology. 153:367-371.
2009
Houck, K.A., D.J. Dix, R.S. Judson, R.J. Kavlock, J. Yang, and E.L. Berg. 2009. Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems. Journal of biomolecular screening. 14:1054-1066.
Schembri, F., S. Sridhar, C. Perdomo, A.M. Gustafson, X. Zhang, A. Ergun, J. Lu, G. Liu, X. Zhang, J. Bowers, C. Vaziri, K. Ott, K. Sensinger, J.J. Collins, J.S. Brody, R. Getts, M.E. Lenburg, and A. Spira. 2009. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. PNAS. doi: 10.1073/pnas.0806383106.
Song, H., H. Wan, Y. Araya, and D. Perez. 2009. Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity. Virology Journal. 6:126.
Tanaka, H., T. Fukushima, K. Yorita, M. Kawaguchi, and H. Kataoka. 2009. Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells. Human Cell. 22:11-17.
Tumpey, and F. Fang. 2009. Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein. PloS one. 4:e7788.
2010
Berg, E.L., J. Yang, J. Melrose, D. Nguyen, S. Privat, E. Rosler, E.J. Kunkel, and S. Ekins. 2010. Chemical target and pathway toxicity mechanisms defined in primary human cell systems. Journal of Pharmacological and Toxicological Methods. 61:3-15.
Lee, Y.H., O. Mungunsukh, R.L. Tutino, A.P. Marquez, and R.M. Day. 2010. Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells. Journal of cell science. 123:1634-1643.
Lung, J., K.-J. Liu, J.-Y. Chang, S.-J. Leu, and N.-Y. Shih. 2010. MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover. FEBS Journal. 277:4308-4321.
Mungunsukh, O., A.J. Griffin, Y.H. Lee, and R.M. Day. 2010. Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology. 298:L696-L703.
Tai, H.Y., M.F. Tam, H. Chou, D.W. Perng, and H.D. Shen. 2010. Pen ch 13 Major Fungal Allergen Decreases CD44 Expression in Human Bronchial Epithelial Cells. International Archives of Allergy and Immunology. 153:367-371.
2008
Lee, Y.H., Y.J. Suzuki, A.J. Griffin, and R.M. Day. 2008. Hepatocyte growth factor regulates cyclooxygenase-2 expression via β-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells. American Journal of Physiology. 294:L778-L786.
2007
Haga, K., S.-i. Ohno, T. Yugawa, M. Narisawa-Saito, M. Fujita, M. Sakamoto, D.A. Galloway, and T. Kiyono. 2007. Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer science. 98:147-154.
Handa, K., T. Yugawa, M. Narisawa-Saito, S.-i. Ohno, M. Fujita, and T. Kiyono. 2007. E6AP-Dependent Degradation of DLG4/PSD95 by High-Risk Human Papillomavirus Type 18 E6 Protein. Journal of Virology. 81:1379-1389.
Horvath, G., E.S. Mendes, N. Schmid, A. Schmid, G.E. Conner, M. Salathe, and A. Wanner. 2007. The effect of corticosteroids on the disposal of long-acting β2-agonists by airway smooth muscle cells. Journal of Allergy and Clinical Immunology. 120:1103-1109.
2006
Tai, H., M. Tam, H. Chou, H. Peng, S. Su, D. Perng, and H. Shen. 2006. Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. 61:382-388.
2005
Lee, S.C., J.Y. Hsu, L.S. Fu, J.J. Chu, S.J. Fan, and C.S. Chi. 2005. Comparison of the activities of granulocyte-macrophage colony-stimulating factor and interleukin-8 secretion between two lung epithelial cell lines. J. microbial., immunol.& infection. 38:327-331.
Look, D.C., L.L. Stoll, S.A. Romig, A. Humlicek, B.E. Britigan, and G.M. Denning. 2005. Pyocyanin and Its Precursor Phenazine-1-Carboxylic Acid Increase IL-8 and Intercellular Adhesion Molecule-1 Expression in Human Airway Epithelial Cells by Oxidant-Dependent Mechanisms. The Journal of Immunology. 175:4017-4023.
2004
Kilani, M., K. Mohammed, N. Nasreen, R. Tepper, and V. Antony. 2004a. RSV Causes HIF-1α Stabilization via NO Release in Primary Bronchial Epithelial Cells. Inflammation. 28:245-251.
Kilani, M.M., K.A. Mohammed, N. Nasreen, J.A. Hardwick, M.H. Kaplan, R.S. Tepper, and V.B. Antony. 2004b. Respiratory syncytial virus causes increased bronchial epithelial permeability*. CHEST Journal. 126:186-191.
2003
O'Malley, Y.Q., K.J. Reszka, G.T. Rasmussen, M.Y. Abdalla, G.M. Denning, and B.E. Britigan. 2003. The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells. American Journal of Physiology. 285:L1077-L1086.
