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Фибробласты кожи человека: HDF. Первичные клеточные линии Cell Applications.

Human Dermal Fibroblasts: HDF

HDF Фибробласты Кожи Человека (HDF) отвечают за выработку клеточного матрикса, формирующего соединительную ткань кожи, и играют важную роль при заживлении ран. HDF от Cell Applications, Inc. обеспечивают прекрасную модель для изучения многих аспектов клеточной физиологии и использовались в десятках исследовательских публикаций, особенно связанных с биологией кожи и перепрограммированием/индуцированием плюрипотентных стадий.

HDF от Cell Applications have been instrumental to

(Текст на языке оригинала)
  • Create and characterize induced pluripotent stem cells (iPSC)
  • Demonstrate the activation and efficiency of reprogramming, such as the transition of fibroblasts into platelets, or mesenchymal stromal cells into iPSC
  • Identify markers that distinguish chondrocytes and synovial cells
  • Establish protocols for tissue engineering, biomaterials, and synthetic collagens.
  • Examine molecular gene regulation & activation, epigenetic modifications, histone ubiquitination and miRNA expression.
  • Describe cell physiology and behavior, includinig cell adhesion, integrins, cartilage link protein and elastic fiber formation. Others rely on the cells to characterize mitochondrial metabolism, angiogenesis and tissue remodeling.
  • Provide insights into disease and pathology: UVA effects, stress-induced premature senescence, skin aging, elasticity and dermal integrity, as well as tumor cell pluripotency markers.
  • Develop potential clinical treatments and therapeutics: Cell survival factors and natural antioxidants like astaxanthin. Some investigators have observed approaches that promote wound healing, or protect skin from UVA-induced photo-aging.

Параметры

Tissue:
Normal human neonatal foreskin or adult skin. Each lot is tested negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Cryopreserved ampoule:
Primary culture, >500,000 cells in Fibroblast Basal Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved HDF (106-05), 500 ml Growth Medium (116-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
Shipped in Growth Medium at 1st passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 16 doublings


Документы



Публикации

2016
Duncan, D., T. Kamerzell and M. Palmer. 2016. Use of Indole Compounds for Fat Reduction and Skin and Soft Tissue Tightening.  Patent Applications US 20160030389 A1.
Lalli, M., J. Jang, J. Park, Y. Wang, E. Guzman, H. Zhou, M. Audouard, D. Bridges, K. Tovar, S. Papuc, A. Tutulan-Cunita, Y. Huang, M. Budisteanu, A. Arghir, and K. Kosik. 2016. Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Human Molecular Genetics, doi: 10.1093/hmg/ddw010.
Sévin, D., J. Stählin, G. Pollak, A. Kuehne and U. Sauer. 2016. Global Metabolic Responses to Salt Stress in Fifteen Species. PLoS ONE 11(2):e0148888. doi:10.1371/journal.pone.0148888.
Sun, X, S. Chakrabarti, J. Fang, Y. Yin and J. Wu. 2016. Low Molecular-Weight Fractions of Alcalase Hydrolyzed Egg Ovomucin Extract Exert Anti-Inflammatory Activity in Human Dermal Fibroblasts through the Inhibition of TNF Mediated NF-κB Pathway. Nutrition Research,        doi:10.1016/j.nutres.2016.03.006.
2015
Alexandra, R., and S. Ramille. 2015. Poly (Ethylene Glycol) Cross-Linking of Soft Materials to Tailor Viscoelastic Properties for Bioprinting. Patent Application 20150084232 A1.
Hozumi, K., C. Fujimori, F. Katagiri, Y. Kikkawa, M. Nomizu. 2015. Suppression of cell adhesion through specific integrin crosstalk on mixed peptide-polysaccharide matrices. Biomaterials, 37:73-81.
Qu, T., J. Cheng, J. Sun, H. Yang, K. Cheng, and J. Shen. 2015. Methods of Attenuating Opioid Tolerance. Patent Application US 20150246074 A1.
Rutz, A., K. Hyland, A. Jakus, W. Burghardt, and R. Shah. 2015. A Multimaterial Bioink Method for 3D Printing Tunable, Cell-Compatible Hydrogels. Advanced Materials, Early View, Online ISSN: 1521-4095.
Wren, M., J. Zhao, C. Liu, M. Murray, Y. Atagi, M. Davis, Y. Fu, H. Okano, K. Ogaki, A. Strongosky, P. Tacik, R. Rademakers, O. Ross, D. Dickson, Z. Wszolek, T. Kanekiyo, and G. Bu. 2015. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Molecular Neurodegeneration, 10:46.
Yamanaka, S. and O. Keisuke. 2015. HIGHLY EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELL.  US Patent Application 20150175973 A1.
Yamanaka, S. and K. Okita. 2015. Method of Nuclear Reprogramming. US Patent Application 20150072417 A1.
Yan, Y., M. Furumura, T. Gouya, A. Iwanaga, K. Teye, S. Numata, T. Karashima, X. Li, and T. Hashimoto. 2015. Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro. Chinese Medical Journal, 128:2228-2233.
2014
Arakawa, M., R. Arakawa, S. Tatsumi, R. Aoki, K. Saito, and A. Nomoto. 2014. A novel evaluation method of survival motor neuron protein as a biomarker of spinal muscular atrophy by imaging flow cytometry. BBRC 453:368-374.
Baboolal, T., S. Boxall, Y. El-Sherbiny, T. Moseley, R. Cuthbert, P. Giannoudis, D. McGonagle and E. Jones. 2014. Multipotential stromal cell abundance in cellular bone allograft: comparison with fresh age-matched iliac crest bone and bone marrow aspirate. Regenerative Medicine, 9:593-607.
Haselmayer, P. M. Camps, M. Muzerelle, S. Bawab, C. Waltzinger, L. Bruns, N. Abla, M. Polokoff, C. Jond-Necand, M. Gaudet, A. Benoit, D. Meier, C. Martin, D. Gretener, M. Lombardi, R. Grenningloh, C. Ladel, J. Petersen, P. Gaillard, and H. Ji. 2014. Characterization of novel PI3Kδ inhibitors as potential therapeutics for SLE and lupus nephritis in pre-clinical studies. Front Immunol, 5:233.
Maekawa, M., K. Yamada, M. Yoyoshima, T. Ohnishi, Y. Iwayama, C. Shimamoto, T. Toyota, Y. Nozake, S. Balan, H. Matsuzaki, Y. Iwata, K. Suzuki, M. Miyashita, M. Kikuchi, M. Kato, Y. Okada, W. Akamatsu, N. Mori, Y. Owada, M. Itokawa, H. Okano, and T. Yoshikawa. 2014. Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. Biological Psychiatry, Online 11 Sep.
Ohsumi, K., M. Watanabe, and A. Fujie. 2014. AS2077715 is a selective inhibitor of fungal mitochondrial cytochrome bc1 complex. The Journal of Antibiotics, 713–716.
Pandian, G.N., J. Taniguchi, S. Junetha, S. Sato, L. Han, A. Saha, C. Anandhakumar, T. Bando, H. Nagase, T. Vaijayanthi, R.D. Taylor, and H. Sugiyama. 2014. Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts. Scientific reports. 4:3843.
2013
Koyanagi-Aoi, M., M. Ohnuki, K. Takahashi, K. Okita, H. Noma, Y. Sawamura, I. Teramoto, M. Narita, Y. Sato, T. Ichisaka, N. Amano, A. Watanabe, A. Morizane, Y. Yamada, T. Sato, J. Takahashi, and S. Yamanaka. 2013. Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. Proceedings of the National Academy of Sciences. 110:20569-20574.
Noguchi, M., K. Hosoda, M. Nakane, E. Mori, K. Nakao, D. Taura, Y. Yamamoto, T. Kusakabe, M. Sone, H. Sakurai, J. Fujikura, K. Ebihara, and K. Nakao. 2013. In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells. Stem cells and development. 22:2895-2905.
Okita, K., T. Yamakawa, Y. Matsumura, Y. Sato, N. Amano, A. Watanabe, N. Goshima, and S. Yamanaka. 2013. An Efficient Nonviral Method to Generate IntegrationFree HumanInduced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells. Stem cells. 31:458-466.
Otagiri, D., Y. Yamada, K. Hozumi, F. Katagiri, Y. Kikkawa, and M. Nomizu. 2013. Cell attachment and spreading activity of mixed laminin peptide–chitosan membranes. Peptide Science. 100:751-759.
Razak, S.R.A., K. Ueno, N. Takayama, N. Nariai, M. Nagasaki, R. Saito, H. Koso, C.-Y. Lai, M. Murakami, and K. Tsuji. 2013. Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns. PloS one. 8:e73532.
Sato, M., S.-i. Maeda, E. Inada, I. Saitoh, and N. Kubota. 2013. Mosaic Expression of Pluripotency-Related Proteins Oct-3/4 and Alkaline Phosphatase in Human Pancreatic Carcinoma Cell PANC-1. Advanced Studies in Biology. 5:157-172.
Tanaka, A., K. Woltjen, K. Miyake, A. Hotta, M. Ikeya, T. Yamamoto, T. Nishino, E. Shoji, A. Sehara-Fujisawa, Y. Manabe, N. Fujii, K. Hanaoka, T. Era, S. Yamashita, K.-i. Isobe, E. Kimura, and H. Sakurai. 2013. Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro. PloS one. 8:e61540.
Yamada, Y., K. Hozumi, F. Katagiri, Y. Kikkawa, and M. Nomizu. 2013. Laminin-111-derived peptide-hyaluronate hydrogels as a synthetic basement membrane. Biomaterials. 34:6539-6547.
Yanagida, A., K. Ito, H. Chikada, H. Nakauchi, and A. Kamiya. 2013. An In Vitro Expansion System for Generation of Human iPS Cell-Derived Hepatic Progenitor-Like Cells Exhibiting a Bipotent Differentiation Potential. PloS one. 8:e67541.
Zheng Q, C.S., Chen Y, Lyga J, Wyborski R, Santhanam U. 2013. Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study. Clinical, Cosmetic and Investigational Dermatology. 6:317-323.
2012
Dell’Agli, M., C. Sanna, P. Rubiolo, N. Basilico, E. Colombo, M.M. Scaltrito, M.O. Ndiath, L. Maccarone, D. Taramelli, and C. Bicchi. 2012. Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area. Malaria journal. 11:1-10.
Hara, R., and H. Kawaguchi. 2012. Highly Sensitive Detection of Telomerase by Using G-Quartet DNA Binder Conjugated Polymeric Microspheres. Kobunshi Ronbunshu, 69:122-128.
Hozumi, K., A. Sasaki, Y. Yamada, D. Otagiri, K. Kobayashi, C. Fujimori, F. Katagiri, Y. Kikkawa, and M. Nomizu. 2012. Reconstitution of laminin-111 biological activity using multiple peptide coupled to chitosan scaffolds. Biomaterials. 33:4241-4250.
Hozumi, K., M. Ishikawa, T. Hayashi, Y. Yamada, F. Katagiri, Y. Kikkawa, and M. Nomizu. 2012. Identification of cell adhesive sequences in the N-terminal region of the laminin α2 chain. Journal of Biological Chemistry. 287:25111-25122.
Kato, Y., Y. Katagata, M. Goto, K. Yamamoto, M. Maeda, Y. Hanada, M. Takai, and Y. Suekawa. 2012. Extract of aquatic animal cartilage. Patent Application US 20130310540 A1.
Mahasiripanth, T., S. Hokputsa, S. Niruthisard, P. Bhattarakosol, and S. Patumraj. 2012. Effects of Acanthus ebracteatus Vahl on tumor angiogenesis and on tumor growth in nude mice implanted with cervical cancer. Cancer management and research. 4:269.
Matsui, T., M. Takano, K. Yoshida, S. Ono, C. Fujisaki, Y. Matsuzaki, Y. Toyama, M. Nakamura, H. Okano, and W. Akamatsu. 2012. Neural Stem Cells Directly Differentiated from Partially Reprogrammed Fibroblasts Rapidly Acquire Gliogenic Competency. Stem cells. 30:1109-1119.
Maucksch, C., E. Firmin, C. Butler-Munro, J. Montgomery, M. Dottori, andn B. Connor. 2012. Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts. J Stem Cells Regen Med, 8:162-170.
Moffett, J., L.M. Fray, and N.J. Kubat. 2012. Activation of endogenous opioid gene expression in human keratinocytes and fibroblasts by pulsed radiofrequency energy fields. Journal of pain research. 5:347.
Oda, Y., H. Ohnishi, S. Yuba, and H. Ohgushi. 2012. Generation of Induced Pluripotent Stem Cells from Mesenchymal Stromal Cells Derived from Human Third Molars (Method). Stem Cells and Cancer, 2:83-93.
Ohta, K. 2012. Method for producing pluripotent cell using bacterium having fermentation ability. Patent Aplication US 20140255942 A1.
Ohta, K., R. Kawano, and N. Ito. 2012. Lactic acid bacteria convert human fibroblasts to multipotent cells. PloS one. 7:e51866-e51866.
Ono, Y., Y. Wang, H. Suzuki, S. Okamoto, Y. Ikeda, M. Murata, M. Poncz, and Y. Matsubara. 2012. Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood. 120:3812-3821.
Rapko, S., and S. Duguay. 2012. Methods of evaluating cells and cell cultures. Patent Application US 20120329051 A1.
Rim, J.S., K.L. Strickler, C.W. Barnes, L.L. Harkins, J. Staszkiewicz, J.M. Gimble, G.H. Leno, and K.J. Eilertsen. 2012. Temporal epigenetic modifications differentially regulate ES cell-like colony formation and maturation. Stem Cell Discovery. 2:45-57.
Sakurai, H., Y. Sakaguchi, E. Shoji, T. Nishino, I. Maki, H. Sakai, K. Hanaoka, A. Kakizuka, and A. Sehara-Fujisawa. 2012. In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells. PloS one. 7:e47078.
Yamanaka, S., K. Takahashi, and K. Okita. 2012. Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2. Patent US 8129187 B2.
Yamanaka, S., K. Takahashi, and K. Okita. 2012. Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2. Patent US 8278104 B2.
Yamanaka, S., K. Takahashi, and K. Okita. 2012. Induced pluripotent stem cells produced with oct3/4, klf and sox. Patent Application US 20130059386 A1.
2011
Connor, B., M. Dottori, and C. Maucksch. 2011. Cell programming. Patent Application US 20120301965 A1.
Deneau, J., T. Ahmed, R. Blotsky, and K. Bojanowski. 2011. Anti-diabetic activity of a mineraloid isolate, in vitro and in genetically diabetic mice. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 81:34-42.
Gao, Z., M.S. Xu, T.L. Barnett, and C.W. Xu. 2011. Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells. Biochemical and biophysical research communications. 407:271-276.
Hirai, H., T. Tani, N. Katoku-Kikyo, S. Kellner, P. Karian, M. Firpo, and N. Kikyo. 2011. Radical Acceleration of Nuclear Reprogramming by Chromatin Remodeling with the Transactivation Domain of MyoD. Stem cells. 29:1349-1361.
Iwabuchi, K., T. Yamakawa, Y. Sato, T. Ichisaka, K. Takahashi, K. Okita, and S. Yamanaka. 2011. ECAT11/L1td1 Is Enriched in ESCs and Rapidly Activated During iPSCGeneration, but It Is Dispensable for the Maintenance and Induction of Pluripotency. PLOS One, DOI: 10.1371/journal.pone.0020461.
Moffett, J., N.J. Kubat, N.E. Griffin, M.C. Ritz, and F.R. George. 2011. Pulsed radio frequency energy field treatment of cells in culture: Increased expression of genes involved in angiogenesis and tissue remodeling during wound healing. The Journal of Diabetic Foot Complications. 3:30-39.
Ohta, S., Y. Imaizumi, Y. Okada, W. Akamatsu, R. Kuwahara, M. Ohyama, M. Amagai, Y. Matsuzaki, S. Yamanaka, and H. Okano. 2011. Generation of human melanocytes from induced pluripotent stem cells. PloS one. 6:e16182.
Rapko, S., and S. Duguay. 2011. Methods of evaluating cells and cell cultures. Patent Application US 20120149013 A1.
Suzuki, M., M. Kitagawa, S. Yamamoto, A. Sogabe, D. Kitamoto, T. Morita, T. Fukuoka, and T. Imura. 2011. Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof. Patent Application US 20120070396 A1.
Yamanaka, S., and K. Takahashi. 2011. Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells. Patent US 8058065 B2.
Yamanaka, S., K. Takahashi, and K. Tanabe. 2011. Efficient method for establishing induced pluripotent stem cells. Patent US 20130267030 A1.
2010
Hayashi, Y., T. Chan, M. Warashina, M. Fukuda, T. Ariizumi, K. Okabayashi, N. Takayama, M. Otsu, K. Eto, M.K. Furue, T. Michiue, K. Ohnuma, H. Nakauchi, and M. Asashima. 2010. Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions. PloS one. 5:e14099.
Li, G., C. Luna, J. Qiu, D.L. Epstein, and P. Gonzalez. 2010. Targeting of integrin β1 and kinesin 2α by microRNA 183. Journal of Biological Chemistry. 285:5461-5471.
Moffett, J., N. Griffin, M. Ritza, and F. George. 2010. Pulsed radio frequency energy field treatment of cells in culture results in increased expression of genes involved in the inflammation phase of lower extremity diabetic wound healing. J Diabetic Foot Complications, 2:57-64.
Nomoto, Y., W. Okano, M. Imaizumi, A. Tani, S. Sato, M. Nomoto, and K. Omori. 2010. Regeneration and Repair Mechanism of the Larynx and Trachea with Hybrid Artificial Scaffold. Koutou, 22:71-76.
Oda, Y., Y. Yoshimura, H. Ohnishi, M. Tadokoro, Y. Katsube, M. Sasao, Y. Kubo, K. Hattori, S. Saito, K. Horimoto, S. Yuba, and H. Ohgushi. 2010. Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. The Journal of biological chemistry. 285:29270-29278.
Rapko, S., M. Zhang, B. Richards, E. Hutto, S. Dethlefsen, and S. Duguay. 2010. Identification of the Chondrocyte Lineage Using Microfibril-Associated Glycoprotein-2, A Novel Marker That Distinguishes Chondrocytes from Synovial Cells. Tissue Engineering Part C: Methods. 16:1367-1375.
Salamone, J., A. Salamone, and M. Lowe. 2010. Conformable bandage and coating material. Patent US 7795326 B2.
Scurr, L.L., G.M. Pupo, T.M. Becker, K. Lai, D. Schrama, S. Haferkamp, M. Irvine, R.A. Scolyer, G.J. Mann, and J.C. Becker. 2010. IGFBP7 is not required for B-RAF-induced melanocyte senescence. Cell. 141:717-727.
Suganuma, K., H. Nakajima, M. Ohtsuki, and G. Imokawa. 2010. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. Journal of dermatological science. 58:136-142.
Takayama, N., S. Nishimura, S. Nakamura, T. Shimizu, R. Ohnishi, H. Endo, T. Yamaguchi, M. Otsu, K. Nishimura, and M. Nakanishi. 2010. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. The Journal of experimental medicine. 207:2817-2830.
Wilmink, G., B. Rivest, B. Ibey, C. Roth, J. Bernhard, and W. Roach. 2010. Quantitative Investigation of the Bioeffects Associated with Terahertz Radiation. Optical Interactions with Tissues and Cells XXI, edited by E. Duco Jansen, Robert J. Thomas, Proc. of SPIE Vol 7562, 75620L. doi: 10.1117/12.844916.
Xu, C. 2010. Reprogramming of somatic cells with purified proteins. Patent Application US 20120115225 A1.
Yamanaka, S. 2010. Nuclear reprogramming factor and induced pluripotent stem cells. Patent Application US 20100210014 A1.
Yamanaka, S. 2010. Nuclear reprogramming factor and induced pluripotent stem cells. Patent Application US 20100216236 A1.
Yamauchi, Y., E. Tsuruga, K. Nakashima, Y. Sawa, and H. Ishikawa. 2010. Fibulin-4 and-5, but not fibulin-2, are associated with tropoelastin deposition in elastin-producing cell culture. Acta histochemica et cytochemica. 43:131.
Yamazaki, C.M., Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, and T. Koide. 2010. A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses. Biomaterials. 31:1925-1934.
Vrba, L., T.J. Jensen, J.C. Garbe, R.L. Heimark, A.E. Cress, S. Dickinson, M.R. Stampfer, and B.W. Futscher. 2010. Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells. PloS one. 5:e8697.
2009
Choi, S. 2009. Die Rolle der Aurora-A Polymorphismen in der Pathogenese des Multiplen Myeloms. German Cancer Research Center (DKFZ), Heidelberg, dissertation.
Del Carmen Velazquez Pereda, M., G. De Campos Dieamant, S. Eberlin, C. Nogueira, D. Colombi, L.C. Di Stasi, and M.L. De Souza Queiroz. 2009. Effect of green Coffea arabica L. seed oil on extracellular matrix components and water-channel expression in in vitro and ex vivo human skin models. Journal of Cosmetic Dermatology. 8:56-62.
Fusaki, N., H. Ban, A. Nishiyama, K. Saeki, and M. Hasegawa. 2009. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proceedings of the Japan Academy, Series B. 85:348-362.
Gupta, A., C. Lobocki, S. Singh, M. Robertson, O.A. Akadiri, G. Malhotra, and I.T. Jackson. 2009. Actions and Comparative Efficacy of Phosphatidylcholine Formulation and Isolated Sodium Deoxycholate for Different Cell Types. Aesth Plast Surg. 33:346-352.
Haferkamp, S., L.L. Scurr, T.M. Becker, M. Frausto, R.F. Kefford, and H. Rizos. 2009. Oncogene-induced senescence does not require the p16INK4a or p14ARF melanoma tumor suppressors. Journal of Investigative Dermatology. 129:1983-1991.
Kitazawa, H., Y. Kasukabe, and M. Kitagawa. 2009. Stress-reducing agent including plant-derived polyamine-containing extract serving as active component. Patent Application US 20110236512 A1.
Li, G., C. Luna, J. Qiu, D.L. Epstein, and P. Gonzalez. 2009. Alterations in microRNA expression in stress-induced cellular senescence. Mechanisms of ageing and development. 130:731-741.
Ohnuki, M., K. Takahashi, and S. Yamanaka. 2009. Generation and characterization of human induced pluripotent stem cells. Current Protocols in Stem Cell Biology, 1Jun, DOI: 10.1002/9780470151808.sc04a02s9.
Panja, A. 2009. Drug Discovery Methods Involving A Preclinical, In Vitro Isolated Gastrointestinal Epithelial Stem Cell-Like Progenitor Cell System. Patent Application US 20090269769 A1.
Suizu, F., Y. Hiramuki, F. Okumura, M. Matsuda, A.J. Okumura, N. Hirata, M. Narita, T. Kohno, J. Yokota, M. Bohgaki, C. Obuse, S. Hatakeyama, T. Obata, and M. Noguchi. 2009. The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt. Developmental Cell. 17:800-810.
Takahashi, K., M. Narita, M. Yokura, T. Ichisaka, and S. Yamanaka. 2009. Human induced pluripotent stem cells on autologous feeders. PloS one. 4:e8067.
Tsubooka, N., T. Ichisaka, K. Okita, K. Takahashi, M. Nakagawa, and S. Yamanaka. 2009. Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. Genes to Cells. 14:683-694.
Yamanaka, S., and K. Okita. 2009. Method of nuclear reprogramming. Patent Application US 20100279404 A1.
2008
Abdull Razis, A., E. Ismail, Z. Hambali, M. Abdullah, A. Ali, and M. Mohd Lila. 2008. Expression of Recombinant Human Epidermal Growth Factor in Escherichia coli and Characterization of its Biological Activity. Appl Biochem Biotechnol. 144:249-261.
Blackwell, T., M. Matsumoto, T. Makino, M. Goto, A. Ishikado, M. Maeda, and S. Azechi. 2008. Phase ii detoxification and antioxidant activity. Patent Application US 20110091587 A1.
Nakagawa, M., M. Koyanagi, K. Tanabe, K. Takahashi, T. Ichisaka, T. Aoi, K. Okita, Y. Mochiduki, N. Takizawa, and S. Yamanaka. 2008. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotech. 26:101-106.
Pappas, J., and P. Yang. 2008. Human ESC vs. iPSC—Pros and Cons. J Cardiovascular Translational Res, 1:96-99.
Razis, A., E. Ismail, Z. Hambali, M. Abdullah, A. Ali, and M. Lila. 2008. Expression of Recombinant Human Epidermal Growth Factor in Escherichia coli and Characterization of its Biological Activity. Appl Biochem and Biotech, 144:249-261.
Shiota, M., H. Izumi, T. Onitsuka, N. Miyamoto, E. Kashiwagi, A. Kidani, A. Yokomizo, S. Naito, and K. Kohno. 2008. Twist Promotes Tumor Cell Growth through YB-1 Expression. Cancer research. 68:98-105.
2006
Behera, A.K., E. Hildebrand, J. Szafranski, H.H. Hung, A.J. Grodzinsky, R. Lafyatis, A.E. Koch, R. Kalish, G. Perides, and A.C. Steere. 2006. Role of aggrecanase 1 in Lyme arthritis. Arthritis & Rheumatism. 54:3319-3329.
Cha, H.S., S. Rosengren, D.L. Boyle, and G.S. Firestein. 2006. PUMA regulation and proapoptotic effects in fibroblastlike synoviocytes. Arthritis & Rheumatism. 54:587-592.
Cochran, S., B. Marshall, T. Barrows, Y. Su, and R. Schlicher. 2006. Hair grafts derived from plucked hair. Patent Application US 20070122387 A1.
2005
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