Anti-EML4: Mouse EML4 Antibody |
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BACKGROUND Echinoderm microtubule-associated proteinlike 4 (EML4) is a 120 kDa microtubule-associated WD repeat protein of the echinoderm microtubule-associated protein family (1). The expression of EML4 is necessary for correct intracellular microtubule network formation (2). EML4 protein expression is upregulated during mitosis and downregulated during the remaining cell cycle (1). During mitosis, EML4 is heavily phosphorylated and is associated with the mitotic spindle (2). The amino-terminal segment of EML4 is essential for microtubule association and function.
REFERENCES
1. Heidebrecht, H.J. et al. (2000) Genomics68, 348-350.
2. Pollmann, M. et al. (2006) Exp. Cell Res.312, 3241-3251.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
| Cat.No.: | CC10044 |
| Antigen: | Recombinant human EML4 expressed mammalian cells. |
| Isotype: | Mouse IgG |
Species & predicted species cross- reactivity ( ): | Human, Mouse |
Applications & Suggested starting dilutions:* | WB 1:1000-1:2000 IP n/d IHC 1:100 ICC 1:100 FACS n/d |
Predicted Molecular Weight of protein: | 20 kDa, 117 KDa (EML4-ALK v1) , 90 KDa (EML4-ALK v3) |
| Specificity/Sensitivity: | Detects endogenous levels of EML4 without cross-reactivity with family members. |
| Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
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