Anti-KLF15: Mouse Kruppel-Like Factor 15 Antibody |
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BACKGROUND Krüppel-like factor 15 (KLF15) is a newly discovered transcription factor that belongs to the Sp1-like/KLF family, which gets its name from a homology to the Drosophila Krüppel protein. Members of this family have been studied for their roles in cell proliferation, differentiation and survival, especially in the context of cancer.
KLF15 is a multifunctional transcriptional regulator that is highly expressed in the liver, kidneys, heart, skin, fat, skeletal muscle, brain, and bone. It was shown that KLF15 plays an important role in glucose homeostasis and lipid accumulation in cells. Insulin differentially regulates KLF15 expression in tissue-specific fashion, up-regulating fat and muscle GLUT4 and AceCS2 gene expression and attenuating hepatic PEPCK gene expression to maintain glucose homeostasis. Indeed, KLF15 plays an important role in the regulation of gluconeogenesis. KLF15 is also a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 genes (HSD17B5) and has a potential role in the pathogenesis of hyperandrogenism.1 Moreover, KLF15 functions as a novel negative regulator of CTGF expression and cardiac fibrosis.2 Mice deficient in KLF15 develop heart failure and aortic aneurysms in a p53-dependent and p300 acetyltransferase–dependent fashion. KLF15 activation inhibits p300-mediated acetylation of p53.3 In addition, KLF15 represses Rhodopsin expression in the inner nuclear layer cells.4
REFERENCES
1. Du, X. et al: J. Clin. Endocrinol. Metabol. 94:2594-2601, 2009
2. Wang, B. et al: J. Mol. Cell. Cardiol. 45:193-7, 2008
3. Haldar, S.M. et al: Sci Transl Med 2:26ra26, 2010
4. Wensel, T.G. et al : Vision Res.45:3445-53, 2005
2. Wang, B. et al: J. Mol. Cell. Cardiol. 45:193-7, 2008
3. Haldar, S.M. et al: Sci Transl Med 2:26ra26, 2010
4. Wensel, T.G. et al : Vision Res.45:3445-53, 2005
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
Cat.No.: | CP10148 |
Antigen: | Purified recombinant human KLF15 fragments expressed in E. coli. |
Isotype: | Mouse IgG1 |
Species & predicted species cross- reactivity ( ): | Human |
Applications & Suggested starting dilutions:* | WB 1:1000 IP n/d IHC n/d ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 44 kDa |
Specificity/Sensitivity: | Detects endogenous KLF15 proteins without cross-reactivity with other family members. |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
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