Anti-Lck: Monoclonal Lymphocyte Cellular Kinase Antibody |
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BACKGROUND Lck (lymphocyte cellular kinase) is a member of the Src family of protein tyrosine kinases, and plays a key role in T-lymphocyte activation and differentiation. Lck is associated with a variety of cell surface receptors and is critical for T-cell antigen receptor (TCR) signal transduction.1 In many non-lymphoid cells, Lck plays an important role in mediating the signaling from cell surface receptor tyrosine kinases to downstream components, e.g. Lck is required for c-Kit-stimulated MAK kinase activation in lung cancer cells.2 In some cancer cells, p56lck could favor metastases by facilitating loss of cell adhesion.3 Under certain conditions Lck is also involved in the induction of apoptosis.4 In addition, Lck is targeted by regulatory proteins of T-lymphotropic viruses, such as the Herpesvirus saimiri (HVS) tyrosine kinase interacting protein (Tip). This oncoprotein physically interacts with Lck in HVS-transformed T cells and impacts its catalytic activity.5 Understanding the regulation of Lck activity may serve as a basis for new drug development capable of modifying Lck activity in different pathological situations.
REFERENCES
1. Palacios, E.H. & Weiss, A. : Oncogene 23:7990, 2004.
2. Bondzi, G. et al. : Cell Growth Differ. 11:305, 2000.
3. Rouer, E. : Bull. Cancer 91:928, 2004.
4. Samraj, A.K. et al. : Oncogene 25:186, 2006.
5. Isakov, N. & Biesinger, B. : Eur. J. Biochem. 267:3413, 2000.
2. Bondzi, G. et al. : Cell Growth Differ. 11:305, 2000.
3. Rouer, E. : Bull. Cancer 91:928, 2004.
4. Samraj, A.K. et al. : Oncogene 25:186, 2006.
5. Isakov, N. & Biesinger, B. : Eur. J. Biochem. 267:3413, 2000.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
Cat.No.: | CB13214 |
Antigen: | Sf9-expressed recombinant human Lck protein |
Isotype: | Mouse Monoclonal IgG1 |
Species & predicted species cross- reactivity ( ): | Human, Mouse, Rat |
Applications & Suggested starting dilutions: | WB 1:1000 IP n/d IHC (Paraffin) n/d ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 56 kDa |
Specificity/Sensitivity: | Anti-Lck antibody specifically detects endogenous levels of Lck proteins, and recognizes human, mouse, & rat Lck. Anti-Lck does not cross-react with other Src-family members. |
Storage: | -20° |
*Optimal working dilutions must be determined by end user.
Документы
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