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TGF-β 3: Human Transforming Growth Factor beta 3


BACKGROUND The Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in a variety of cells. Recent data suggest that individual TGF-β isoforms (TGF-β 1, -β 2 and _β 3) have overlapping, yet distinct biological actions and target cell specificities, both in developing and adult tissues. TGF-β3 is a new isoform that is presumed to play an important role in wound repair and scarring. TGF-β 3 is also thought to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis.

Recombinant human TGF-β 3 is a non-glycosylated, disulfide-linked homodimer. Each monomer is 112 amino acids, having a total molecular mass of 25.5 kDa.

Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat. No.:
RP1109
 
Alternative Name:
None
 
Source:
E. coli
 
Physical Appearance:
Sterile filtered clear solution.
 
Formulation:
Recombinant human TGF-β 3 is provided in a solution (0.25 mg/ml) that contains 20% Ethanol and 0.12% Acetic Acid.
 
Stability:
Stable at 4°C for 1 year from date of purchase.
 
Reconstitution:
Not applicable.
 
Protein Content and Purity determined by:
UV spectroscopy at 280 nm.
RP-HPLC calibrated against a known standard.
Quantitation against a known standard via reducing and non-reducing SDS-PAGE gels.
 
Endotoxin Level:
Endotoxin level, as measured by LAL analysis, is <0.01ng/ug or <0.1EU/ug.
 
Biological Activity:
The activity is determined by the cell toxicity assay, using the WHO Standard 98/608 as a direct comparison, and is typically less than 0.05 ng/mL.
 
AA Sequence:
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
 


Документы



НазваниеКодЦена
Human Transforming Growth Factor beta 3 RP1109-10 по запросу
Human Transforming Growth Factor beta 3 RP1109-100 по запросу
Human Transforming Growth Factor beta 3 RP1109-1000 по запросу




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