TNF-α: Mouse Tumor Necrosis Factor alpha

BACKGROUND Tumor Necrosis Factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS. TNF-α activates signals through two receptors, TNF-R1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells. TNF-α can have many functions including, to stimulate of phagocytosis in macrophages, to chemoattract neutrophils, to increase insulin resistance and to induce fever.

Recombinant mouse TNF-α is a non-glycosylated protein, containing 156 amino acids and having a molecular mass of 17.3 kDa.

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