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Anti-AQP4: Polyclonal Aquaporin 4 Antibody


BACKGROUND Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, which is abundantly expressed in astrocytes throughout the central nervous system, particularly at the blood-brain and brain-cerebrospinal fluid barriers.1 AQP4 mediates bidirectional transport of water across astrocytes.  Phenotype analysis of transgenic mice lacking AQP4 has provided compelling evidence for involvement of AQP4 in cerebral water balance, astrocyte migration, and neural signal transduction.2 AQP4 manipulation may serve as a novel therapeutic strategy for a variety of cerebral disorders including stroke, tumor, infection, hydrocephalus, epilepsy, and traumatic brain injury.3
 
REFERENCES
1. Manley GT et al.: Neuroscience, 129:983-91, 2004.
2. Verkman AS et al.: Biochim Biophys Acta. 1758:1085-93, 2006.
3. Manley GT et al.: Nat Med. 6:159-63, 2000.
 
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CA1220
Antigen:
Peptide containing the middle region sequence of human AQP4.
Isotype:
Rabbit Polyclonal
Species & predicted
species cross-
reactivity ( ):
Human, Mouse
Applications &
Suggested starting
dilutions:
WB                  1:1000
IP                    1:50
IHC (Paraffin)  1:100
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
37 kDa
Specificity/Sensitivity:
Detects endogenous levels of AQP4 protein in  normal primary cell lysates.
Storage:
Store at 4° C for frequent use; at -20° C for at least one year.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Polyclonal Aquaporin 4 Antibody CA1220 по запросу




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