1. Каталог >
  2. Клеточные линии, штаммы, среды >
  3. Клеточная биология >
  4. Антитела >

Anti-ARK1/GRK2: Mouse ARK1/GRK2 Antibody


BACKGROUND Beta-Adrenergic Receptor Kinase (beta-ARK1), also known as GRK2, is a member of the Serine /Threonine G protein-coupled receptor kinase superfamily.1 It phosphorylates the beta-2-Adrenergic Receptors and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This kinase is a ubiquitous cytosolic enzyme that regulates cardiac output and activity in response to catecholamines. It modulates beta-AR activity and abrogats beta-AR-dependent signals by directly phosphorylating the receptors.2 Amounts of beta-ARK1 are increased in cardiac disease, where cardiac output is below normal, suggesting that the impairment of beta-AR activity could lead to certain forms of heart disease. Thus, there is great interest in generating therapeutic agents that can modulate the activity of the beta-ARK1.3
 
REFERENCES  
1. Rockman, H.A. et al: Nature 415:206-12, 2002
2. Hausdorff, W.P. et al: FASEB J. 4:2881-9, 1990
3. Hata, J.A. & Koch, W.J.: Mol. Intervent. 3:264-72, 2003
  
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CP10374
Antigen:
Raised against purified recombinant fragments of human ARK1/GRK2 expressed in E. Coli.
Isotype:
Mouse IgG1
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
dilutions:*
WB                  1:1000
IP                    n/d
IHC                  1:50 - 1:200
ICC                  1:50 - 1:200
FACS               n/d
Predicted Molecular
Weight of protein:
80 kDa
Specificity/Sensitivity:
Detects ARK1/GRK2 proteins without cross-reactivity with other family members.
Storage:
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Mouse ARK1/GRK2 Antibody CP10374 по запросу




Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой