Anti-Axl: Polyclonal Axl Antibody |
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BACKGROUND The Axl receptor (also named UFO and Ark) is a receptor tyrosine kinase and was first identified as a transforming gene in chronic myeloid leukemia. It is part of a family of receptor tyrosine kinases that includes c-Mer and Sky/Rse and is expressed ubiquitously.1 The Axl protein has a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. Intracellular signaling is mediated by a multi-substrate docking site, which meidated activation of phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB.2 It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Because several metastatic cell types overexpress Axl, another role of the receptor may be played during invasion and metastasis.3
REFERENCES
1. O'Bryan JP et al.: Mol. Cell. Biol. 11: 5016–31, 1991.
2. Goruppi S et al.: Mol. Cell. Biol. 17: 4442-4453, 1997.
3. Holland SJ et al.: Cancer Research 65:9294-9303, 2005.
2. Goruppi S et al.: Mol. Cell. Biol. 17: 4442-4453, 1997.
3. Holland SJ et al.: Cancer Research 65:9294-9303, 2005.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
Cat.No.: | CC1045 |
Antigen: | Sequence near the human Axl carboxyl terminal. |
Isotype: | Affinity Purified Rabbit IgG |
Species & predicted species cross- reactivity ( ): | Human, Mouse, Rat |
Applications & Suggested starting dilutions: | WB 1:1000 IP n/d IHC (Paraffin) n/d ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 140 kDa |
Specificity/Sensitivity: | Detects endogenous levels of Axl proteins in various cell lysates. |
Storage: | Store at 4° C for frequent use; at -20° C for at least one year. |
*Optimal working dilutions must be determined by end user.
Документы
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