Anti-BMP-4: Monoclonal Bone Morphogenic Protein-4 Antibody |
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BACKGROUND Bone morphogenetic protein 4 (BMP-4) is a polypeptide belonging to the TGF-betaTGF superfamily of proteins. Like other bone morphogenetic proteins, BMP-4 is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development.1 In human embryonic development, BMP-4 is a critical signaling molecule required for the early differentiation of the embryo and establishment of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures.2 BMP-4 stimulates differentiation of overlying ectodermal tissue.3 Inhibition of the BMP-4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.
REFERENCES
1. Chen, D. et al., Growth Factors 22:233, 2004.
2. Aberdam, D. et al., Bull. Acad. Natl. Med. 189:645, 2005.
3. Czyz, J. & Wobus, A., Differentiation 68:167, 2001.
2. Aberdam, D. et al., Bull. Acad. Natl. Med. 189:645, 2005.
3. Czyz, J. & Wobus, A., Differentiation 68:167, 2001.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
Cat.No.: | CB12470 |
Antigen: | NSO-expressed recombinant human BMP-4 protein |
Isotype: | Mouse Monoclonal IgG1 |
Species & predicted species cross- reactivity ( ): | Human, Mouse |
Applications & Suggested starting dilutions: | WB 1:1000 IP n/d IHC (Paraffin) n/d ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 47 kD |
Specificity/Sensitivity: | Does not cross-react with other BMP family proteins |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
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