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Anti-Cytochrome C: Polyclonal Cytochrome C Antibody


BACKGROUND Cytochromes c (cyt c) is a memeber of family of electron¬transfer proteins having one or several haem c groups, bound to the protein by one or, more commonly two, thioether bonds involving sulphydryl groups of cysteine residues. The fifth haem iron ligand is always provided by a histidine residue. Cyt c possess a wide range of properties and function in a large number of different redox processes.1 It is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family.2 As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions.3
 
REFERENCES
1. Adman ET: Biochim. Biophys. Acta 549:107-144, 1979.
2. Jiang X & Wang X: Ann. Rev. Biochem., 73: 87-106, 2004.
3. Ow YLP et al.: Nat.  Rev. Mol. Cell Biol. 9:532-542, 2008.
 
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CC1042
Antigen:
Sequence near the human Cytochrome C N-terminal.
Isotype:
Affinity purified rabbit IgG
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
dilutions:
WB                  1:1000
IP                    n/d
IHC (Paraffin)  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
14 kDa
Specificity/Sensitivity:
Detects detects endogenous Cytochrome C proteins in various cell lysates.
Storage:
Store at 4° C for frequent use; at -20° C for at least one year.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Polyclonal Cytochrome C Antibody CC1042 по запросу




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