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Anti-Elk1: Mouse Elk1 Antibody


BACKGROUND Elk1 is a member of ETS-domain transcription factor family. ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis.1 Elk-1 is regulated by phosphorylation in response to activation of the MAPK (mitogen-activated protein kinase) pathways. This phosphorylation triggers a series of molecular events that convert Elk-1 from a transcriptionally silent state into a highly active state and then back to a basal level.2 At the same time, activation of the ERK (extracellular-signal-regulated kinase) MAPK pathway leads to loss of modification of Elk-1 by SUMO (small ubiquitin-related modifier). As SUMO imparts repressive properties on Elk-1, ERK-mediated SUMO loss leads to de-repression at the same time as the ERK pathway promotes activation of Elk-1.3 Thus a two-step mechanism is employed to convert Elk-1 into its fully activated state.
 
REFERENCES  
1. Tsu, T. et al.: J. Cell. Biochem. 91:896, 2004.
2. Yang, S. H. & Sharrocks, A. D.: Biochem. Soc. Symp. 73:121, 2006.
3. Yang, S. H. et al.: Mol. Cell 12:63, 2003.
  
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CB13452
Antigen:
E. coli-expressed recombinant human Elk1 protein.
Isotype:
Mouse Monoclonal IgG1
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
dilutions:*
WB                  1:1000
IP                    n/d
IHC                  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
62 kDa
Specificity/Sensitivity:
Detects Elk1 protein and does not cross-react with related proteins.
Storage:
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Mouse Elk1 Antibody CB13452 по запросу




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