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Anti-Noggin: Monoclonal Noggin Antibody


BACKGROUND The gene noggin, originally cloned in Xenopus, encodes a secreted factor expressed in the Spemann organizer, where it functions to oppose the ventralizing influence of bone morphogenetic proteins (BMPs). Noggin protein acts by binding directly to BMPs, thereby preventing them from interacting with their receptors. The interaction between BMPs and Noggin, is critical for normal development.1 Recently, it was shown that Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. This feeder-free culture system will provide a more reliable alternative for future therapeutic applications of hES cells.2
 
REFERENCES  
1. MacMahon, J. A. et al., Gene Dev 12:1438, 1998.
2. Wang, G. et al., Biochem Biophys Res Commun 330:934, 2005. 
  
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CB10536
Antigen:
Recombinant human Noggin protein
Isotype:
Mouse Monoclonal IgG1
Species & predicted
species cross-
reactivity ( ):
Human
Applications &
Suggested starting
dilutions:*
WB                  1:1000
IP                    n/d
IHC                  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
27 kDa
Specificity/Sensitivity:
Reacts specifically with human Noggin in Western Blot applications.
Storage:
-20°


*Optimal working dilutions must be determined by end user.



Документы



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Monoclonal Noggin Antibody CB10536 по запросу




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