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Anti-Syk: Mouse Syk Antibody


BACKGROUND Spleen tyrosine kinase (Syk) is a non-receptor protein tyrosine kinase expressed in a wide range of hematopoietic cells.1 Syk has not only been recognized as a key player in both innate and adaptive immunity, but there is also evidence of a role for Syk in non-immune cells and in the maintenance of vascular integrity,2 as well as the pathogenesis of malignant cancer.3 Syk contains two SH2 domains in tandem, and multiple auto-phosphorylation sites. Syk is activated upon binding of tandem SH2 domains to the immuno-receptor tyrosine-based activating motif (ITAM) of various types of receptors such as Fc-gamm-R, CR3, Dectin-1, and apoptotic cell-recognizing receptor. Syk is critical for the tyrosine phosphorylation of multiple proteins which regulate important pathways downstream of the receptor, such as Ca2+ mobilization, mitogen-activated protein kinase (MAPK) cascades, PI-3 kinase pathway and many other signaling pathways.4
 
REFERENCES  
1. Nilsson, S. et al: Physiol Rev 81:1535–65, 2001.
2. Tremblay, G. B. et al: Mol Endocrinol. 11: 353-365, 1997.
3. Mathews, J & Gustafsson, J. A.: Mol. Interv. 3:281-92, 2003.
4. Tremblay, A. et al: Mol Cell 3, 513–519, 1999. 
  
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Параметры

Cat.No.:
CP10233
Antigen:
Purified recombinant human Syk fragments expressed in E. coli.
Isotype:
Mouse IgG1
Species & predicted
species cross-
reactivity ( ):
Human, Mouse
Applications &
Suggested starting
dilutions:*
WB                  1:1000
IP                    n/d
IHC                  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
72 kDa
Specificity/Sensitivity:
Detects endogenous Syk proteins without cross-reactivity with other family members.
Storage:
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.



Документы



НазваниеКодЦена
Mouse Syk Antibody CP10233 по запросу




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