1. Каталог >
  2. Клеточные линии, штаммы, среды >
  3. Клеточная биология >
  4. Антитела >

Anti-α1-Catenin: Rabbit alpha1 Catenin Antibody

BACKGROUND Alpha-Catenin functions as a linking protein between cadherins and actin-containing filaments of the cytoskeleton. It has been reported that the actin binding proteins vinculin and alpha-actinin can bind to alpha-Catenin. However, a protein complex including a cadherin, actin, beta-Catenin and alpha-Catenin has not been isolated. It has been suggested that alpha-Catenin does not bind with high affinity to both actin filaments and the E-Cadherin-beta-Catenin complex at the same time.1 It has been observed that when alpha-Catenin is not in a molecular complex with beta-Catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.2 The amino acid sequence of alpha-Catenin has sequence similarity to that of vinculin. There are three human alpha-Catenin genes: alpha-1-Catenin (also called alpha-E-Catenin), alpha-2-Catenin (also called alpha-N-Catenin), and alpha-3-Catenin (also called alpha-T-Catenin).
1. Yamada, S. et al: Cell 123:889-901, 2005
2. Drees, S. et al: Cell 123:903-915, 2005 
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


Synthesized peptide derived from human Catenin-α1.
Rabbit IgG
Species & predicted
species cross-
reactivity ( ):
Human, Rat, Mouse
Applications &
Suggested starting
WB                  1:500-1:1000
IP                    n/d
IHC                  1:50-1:100
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
100 kDa
Detects endogenous α1-Catenin without cross-reactivity with other family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.


Rabbit alpha1 Catenin Antibody CG1654 по запросу

Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой