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Anti-DDR1: Polyclonal Discoidin Domain Receptor 1 Antibody

BACKGROUND Discoidin domain receptors (DDRs) are a subfamily of transmembrane collagen-binding receptor tyrosine kinases (RTK). DDRs are distinguished from other RTKs by a discoidin domain in their extracellular region, which functions as a lectin in the slime mold Dictyostelium discoideum. There are two genes that code for DDRs in humans, DDR1 and DDR2. Each DDR contains an extracellular region containing the ligand-binding discoidin domain, a stalk region, and a single transmembrane region, as well as a cytoplasmic domain consisting of a juxtamembrane region and a tyrosine kinase domain.1 Expression of DDR1 protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. Aberrant expression and signaling of DDR1 proteins have been implicated in several human diseases linked to accelerated matrix degradation and remodeling, including tumor invasion, atherosclerosis, and liver fibrosis.2 The activation and autophosphorylation of DDR1 are achieved by treatment of cells with triple-helical collagens.3 DDR1 has been found to play a role in cell attachment, migration, cell survival and proliferation.
1. Abdulhussein, R. et al: J. Biol. Chem. 283:12026-12033, 2008.
2. Sakamoto, O. et al: Eur Respir J., 17:969-974, 2001.
3. Abdulhussein, R. et al: J. Biol. Chem. 279:31462-31470, 2004.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


An epitope near the human DDR1 carboxyl terminal sequence.
Rabbit Polyclonal IgG
Species & predicted
species cross-
reactivity ( ):
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC (Paraffin)  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
115 kDa
This antibody detects human DDR1 proteins in transfected cell lysate.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
 *Optimal working dilutions must be determined by end user.


Polyclonal Discoidin Domain Receptor 1 Antibody CC1016 по запросу

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