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Anti-IL-1Ra: Monoclonal IL-1 Receptor Antagonist Antibody

BACKGROUND The IL-1 family of cytokines is produced by activated monocytes/macrophages during the acute phase of inflammatory response. The IL-1 cytokines are also produced by a variety of other cells including neutrophiles,  keratinocytes, epithelial cells, fibroblasts, adrenal cortical and medullary cells.1 The cytokine IL-1 and IL-1 have a 25% homology in amino acids. The biological action of IL-1 cytokines is the results of their binding to the IL-1 receptor type I (Rt1). A  second IL-1 receptor (Rt2)  does not produce any biological effect  and most probably represents a “decoy receptor”.  A third member of IL-1 family of cytokines  is  IL-1 receptor antagonist (IL-1 Ra), which exhibits same binding affinity to both types of IL-1 receptors,  but  without inducing a biological response,  thus antagonizing the effects of IL-1.2 Interestingly, the action of IL-1 Ra is not restricted to the counterregulation of inflammatory processes. IL-1 Ra has been shown to be upregulated in the serum of obese subjects.3
1. Carter, D. B. et al: Nature. 344:633, 1990.
2. Granowitz, E. V. et al: J. Biol. Chem. 266:14147, 1991.
3. Saltevo, J. et al: Diab Vasc Dis Res. 4:328, 2007.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


E. coli-expressed recombinant human IL-1Ra protein.
Mouse IgG1
Species & predicted
species cross-
reactivity ( ):
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC (paraffin)   n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
17 kDa
Detects human IL-Ra proteins. Does not cross-react with other IL-1 family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

 *Optimal working dilutions must be determined by end user.


Monoclonal IL-1 Receptor Antagonist Antibody CB19846 по запросу

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