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Anti-Lck: Mouse Lck Antibody

BACKGROUND Lck belongs to the Src-like non-receptor tyrosine kinase family with the typical Src family kinase structure: a unique amino terminal domain (Src homology 4 domain, SH4) followed by an SH3 domain, an SH2 domain, a kinase domain (SH1), and a carboxyl terminal negative regulatory domain (1). Lck activity is controlled by the interactions of SH2 and SH3 domains as well as tyrosine phosphorylation status of the activation loop (2, 3). Lck is recruited to the T cell receptor (TCR) complex upon stimulation and activates downstream tyrosine kinases to initiate T cell signaling (4). Lck is also found to be involved in the regulation of mitochondrial apoptosis pathways and may be responsible for some anticancer drug induced apoptosis (5, 6).

1.  Palacios, E.H. and Weiss, A. (2004) Oncogene 23, 7990–8000.
2. Mustelin, T. and Taskén, K. (2003) Biochem J 371, 15–27.
3. Gervais, F.G. et al. (1993) Mol Cell Biol 13, 7112–21.
4. Straus, D.B. and Weiss, A. (1992) Cell 70, 585–93.
5.  Belka, C. et al. (2003) Oncogene 22, 176–85.

6. Gruber, C. et al. (2004) Biochem Pharmacol 67,1859–72

Products are for research use only. They are not intended for human, animal, or diagnostic applications.


Antigen:Recombinant human Lck expressed in Sf9 cells
Isotype:Rabbit IgG1
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC                  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
56 kDa
Specificity/Sensitivity:Detects endogenous Lck proteins without cross-reactivity with other family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.
*Optimal working dilutions must be determined by end user.

Mouse Lck Antibody CC10051 по запросу

Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой