Anti-AurkB: Monoclonal Aurora Kinase B Antibody |
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BACKGROUND Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B (AurkB) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AurkB functions in the attachment of the mitotic spindle to the centromere.1 In cancerous cells, over expression of these enzymes cause unequal distribution of genetic information creating aneuploidy cells, a hallmark of cancer. Thus, AurkB is emerging as a novel drug target for cancer treatment.2, 3
REFERENCES
1. Shannon, K. B. & Salmon, E.D.: Curr Biol. 12:R458, 2002.
2. Mahadevan, D. et al.: Curr Med Chem Anticancer Agents 3:25, 2003.
3. Vischioni, B. et al.: Mol. Cancer Ther. 5:2905, 2006.
2. Mahadevan, D. et al.: Curr Med Chem Anticancer Agents 3:25, 2003.
3. Vischioni, B. et al.: Mol. Cancer Ther. 5:2905, 2006.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
Параметры
Cat.No.: | CB12146 |
Antigen: | Recombinant human Aurora Kinase B protein |
Applications & Suggested starting dilutions:* | WB 1:1000 IP n/d IHC n/d ICC n/d FACS n/d |
Molecular Weight of protein(KDa): | 41 kDa |
Species & predicted species cross-reactivity ( ): | Human, Mouse, Rat |
Specificity/Sensitivity: | Does not cross-react with other Aurora Kinase family proteins |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
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