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Anti-AurkB: Monoclonal Aurora Kinase B Antibody

BACKGROUND Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B (AurkB) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AurkB functions in the attachment of the mitotic spindle to the centromere.1 In cancerous cells, over expression of these enzymes cause unequal distribution of genetic information creating aneuploidy cells, a hallmark of cancer. Thus, AurkB is emerging as a novel drug target for cancer treatment.2, 3
1. Shannon, K. B. & Salmon, E.D.: Curr Biol. 12:R458, 2002.
2. Mahadevan, D. et al.: Curr Med Chem Anticancer Agents 3:25, 2003.
3. Vischioni, B. et al.: Mol. Cancer Ther. 5:2905, 2006.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


Recombinant human Aurora Kinase B protein
Applications & Suggested starting dilutions:*
WB                1:1000
IP                  n/d
IHC                n/d
ICC                n/d
FACS             n/d
Molecular Weight of protein(KDa):
41 kDa
Species & predicted species cross-reactivity ( ):
Human, Mouse, Rat
Does not cross-react with other Aurora Kinase family proteins
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

*Optimal working dilutions must be determined by end user.


Monoclonal Aurora Kinase B, AurkB, Antibody CB12146 по запросу

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