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Anti-Phospho ErbB2: Polyclonal ErbB2, Phospho-Tyr1221/2 Antibody

BACKGROUND ErbB2 (also called Her2, Neu, and CD340) is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family.  It is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. However, ErbB receptors dimerise on ligand binding, and ErbB2 is the preferential dimerisation partner of other members of the ErbB family.1,2  ErbB2 is notable for its role in the pathogenesis of breast cancer and as a target of treatment. Approximately 15-20 percent of breast cancers have an amplification of the ErbB2 gene or overexpression of its protein product. It  is important as the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is only effective in breast cancer where the ErbB2 receptor is overexpressed.3
1. Revillion, F. et al:  Eur. J. Cancer  34 :791, 1998
2. Hynes, N. E & Lane, H. A.:  Nat Rev Cancer.  5:341, 2005
3. Olayioye, M. A. :  Breast Cancer Res 3:385, 2001
Products are for research use only. Not intended for human, animal, or diagnostic applications.


KLH-conjugated peptide containing human ErbB2 Tyr1221/2 surrounding sequence.
Rabbit IgG
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC (paraffin)   n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
185 kDa
Detects endogenous levels of ErbB2 proteins when phosphorylated at Tyr1221/2. Does not cross-react with other Erb family members.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

 *Optimal working dilutions must be determined by end user.

Polyclonal ErbB2, Phospho-Tyr1221/2 Antibody CB4236 по запросу

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