1. Каталог >
  2. Клеточные линии, штаммы, среды >
  3. Клеточная биология >
  4. Антитела >

Anti-LSD1: Monoclonal Lysine-Specific Demethylase 1 Antibody (2H5)

BACKGROUND Lysine-specific demethylase 1 (LSD1; also known as BHC110) is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9).1 Through a FAD-dependent oxidative reaction, LSD1 speficially removes histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9 (H3-K9), thereby leading to de-repression of androgen receptor target genes.2 Functions of other components in LSD1 complex, such as CoREST and BHC80, as well as p53, have been further studied.3, 4 It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.
1. Forneris, F. et al: Trends Biochem Sci.33:181, 2008.
2. Culhane,  J.C. & Cole, P. A.: Curr Opin Chem Biol. 11:561, 2007.
3. Urbanucci, A. et al: BMC Cancer. 8:219, 2008.
4. Tsai, W.W. et al: Mol. Cell. Biol. 28:5139, 2008.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.


E. coli-expressed recombinant human LSD1 protein fragments.
Mouse monoclonal IgG1
Species & predicted
species cross-
reactivity ( ):
Human, Mouse, Rat
Applications &
Suggested starting
WB                  1:1000
IP                    n/d
IHC (Paraffin)  n/d
ICC                  n/d
FACS               n/d
Predicted Molecular
Weight of protein:
110 kDa
Specifically detects endogenous levels of LSD1 proteins. Does not cross-react with other related proteins.
Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.

 *Optimal working dilutions must be determined by end user.


Monoclonal Lysine-Specific Demethylase 1 Antibody (2H5) CB18672 по запросу

Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой