| |
Клик-химия Click Chemistry Reagents
| |
Клик-химия[1] описывает пары функциональных групп, которые быстро и специфически реагируют ("click") друг с другом в мягких условиях в водной среде. Концепция Клик-химии трансформировалась в удобную, универсальную и надежную двухступенчатую процедуру соединения двух молекул А и Б[1-5], которая широко используется в биологии[6-8], разработке лекарственных препаратов[9] материаловедении[10].
Клик-химия: справочная информацияКлик-реагенты по химическим группам | Клик-реагенты по применению ... на ДНК ...на РНК
|
 | Реагенты для Клик-химии |  | CLICK- флуоресцентные красители |  | CLICK- мечение клеточных метаболитов |
Использованные источники:
Введение в концепцию Клик-химии
[1] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[2] Sletten et al. (2009) Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality. Angew. Chem. Int. Ed.48:6998.
[3] Jewett et al.(2010) Cu-free click cycloaddition reactions in chemical biology. Chem. Soc. Rev. 39(4):1272.
[4] Best et al. (2009) Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules. Biochemistry.48:6571.
[5] Lallana et al. (2011) Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide—Alkyne Cycloadditions. Angew. Chem. Int. Ed. 50:8794.
Обзор применений Клик-химии
[6] Grammel et al. (2013) Chemical Reporters for biological discovery. Nature Chemical Biology 9:475.
[7] Xie et al. (2013) Cell-selective metabolic labeling of biomolecules with bioorthogonal functionalities. Current Opinion in Chemical Biology 17:747.
[8] Su et al. (2013) Target identification of biologically active small molecules via in situ methods. Current Opinion in Chemical Biology 17:768.
[9] Zeng et al. (2013) The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals. J Nucl Med 54:829.
[10] Evans et al. (2007) The Rise of Azide—Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification. Australian Journal of Chemistry 60(6):384.
Введение в концепцию Клик-химии
[1] Kolb et al. (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40 (11):2004.
[2] Sletten et al. (2009) Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality. Angew. Chem. Int. Ed.48:6998.
[3] Jewett et al.(2010) Cu-free click cycloaddition reactions in chemical biology. Chem. Soc. Rev. 39(4):1272.
[4] Best et al. (2009) Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules. Biochemistry.48:6571.
[5] Lallana et al. (2011) Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide—Alkyne Cycloadditions. Angew. Chem. Int. Ed. 50:8794.
Обзор применений Клик-химии
[6] Grammel et al. (2013) Chemical Reporters for biological discovery. Nature Chemical Biology 9:475.
[7] Xie et al. (2013) Cell-selective metabolic labeling of biomolecules with bioorthogonal functionalities. Current Opinion in Chemical Biology 17:747.
[8] Su et al. (2013) Target identification of biologically active small molecules via in situ methods. Current Opinion in Chemical Biology 17:768.
[9] Zeng et al. (2013) The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals. J Nucl Med 54:829.
[10] Evans et al. (2007) The Rise of Azide—Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification. Australian Journal of Chemistry 60(6):384.
Информация представлена исключительно в ознакомительных целях и ни при каких условиях не является публичной офертой
