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Клетки эндотелия пупочной вены человека: HUVEC. Первичные клеточные линии Cell Applications.

Human Umbilical Vein Endothelial Cells: HUVEC

HUVEC Клетки Эндотелия Пупочной Вены Человека (HUVEC) предоставляют классическую модельную систему для изучения многих аспектов функций и заболеваний эндотелия, таких как нормальный, аномальный и связанных с опухолями ангиогенез, оксидативный стрес, гипоксия и воспаления, связанные с ними сигнальные пути в эндотелии в нормальных и патологических условиях, связанные с сердечно-сосудистые осложнения, связанные с различными заболеваниями, способы действия и защитные эффекты различных соединений и т.д.  Избранные лоты HUVEC были дополнительно тестированы для демонстрации стимуляционно-зависимого ангиогенеза и ключевых для эндотелиальных клеток сигнальных путей (фосфорилирование VEGFR, Akt, MAPK, и экспрессию Tie2, eNOS, Axl и Etk/Bmx). Более подробную информацию смотрите в разделе Тестированные Эндотелиальные Клетки.

HUVEC от Cell Applications, Inc. были использованы во многих исследованиях, например:

(Текст на языке оригинала)
  • Understand anti-inflammatory properties of HDL
  • Develop scaffolds for tissue engineering
  • Characterize endothelial cell response to stress and discover mechanisms that protect mitochondria against oxidative stress
  • Demonstrate that prolonged hypoxia induces MMP-1 expression, EC migration and angiogenesis
  • Show that Alzheimer’s β-amyloid peptide exhibits anti-angiogenic properties
  • Demonstrate for the first time that mature miRNA can control gene expression in a cell where it is neither transcribed nor processed
  • Show that abnormal matrix composition characteristic for systemic sclerosis leads to impaired vascular function and angiogenesis
  • Discover novel mechanisms of inhibiting tumor angiogenesis and metastasis, by limiting EC migration and proliferation, as well as the expression of growth factors and enzymes
  • Develop a bubble lyposome based system that enables therapeutic miRNA delivery
  • Demonstrate that commercially used flame retardants cause oxidative stress
  • Show that hyperglycemia leads to endothelial dysfunction, partially due to depletion of antioxidants, and that regaining glycemic control normalizes growth factor levels in ischemia and improves perfusion recovery
  • Show that inhibition of aldose reductase inhibits migration and formation of capillary-like structures by endothelial cells
  • Investigate effects of molecular mobility of the outmost material surfaces on cellular adhesion and organization
  • Identify signaling differences in cells cultured on different ECM components.
  • Investigate mechanisms of cardiovascular protection exerted by bioactive plant and fungal components
  • Show that in low doses coumaric acid and resveratrol provide beneficial effects and protect endothelial cells from reactive oxygen species
  • Show that combined treatment with melatonin and atorvastatin reversed damage to EC, partly by reducing free radical generation and lipid peroxidation
  • Discover that deferoxamine (DFO), an iron-chelating agent, mitigates deleterious effects of radiation on angiogenesis
  • Study the differential effects of wood smoke and diesel exhaust particles, as well as carbon nanotubes on inducing oxidative stress and production of cytokines and adhesion molecules in endothelia


Human normal umbilical vein.  Each lot is tested negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Cryopreserved ampoule:
Primary culture, >500,000 cells in Endothelial Cell Basal Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved HUVEC (200-05n), 500 ml Endothelial Cell Growth Medium (211-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
Shipped in Endothelial Cell Transfer Medium at 1st passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 16 doublings



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For general cryopreservation of most primary cells. Contains FBS & DMSO. 040-50 по запросу

HUVEC Total Kit: Media, Subculture Reagents & Cells, Fetal 200K-05f по запросу
HUVEC Total Kit: Media, Subculture Reagents & Cells, Neonatal 200K-05n по запросу
HUVEC Total Kit: Media, Subculture Reagents & Cells, Pooled, Neonatal 200pK-05n по запросу

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Cryopreserved HUVEC 200-05f по запросу

Cryopreserved Ampoule, pooled 200p-05n по запросу
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25 x 24-Well Rxns TF200KS по запросу
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Basal medium (contains no growth supplement).В  Add GS before use. 210-500 по запросу
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Basal medium & growth supplement sold together packaged separately 211K-500 по запросу

Starvation medium without phenol red 209PR-250 по запросу
Use when cells need to be starved overnight to 24 hrs before experiment 209-250 по запросу

Proliferating HUVEC 201-6Wf по запросу
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100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution 090K по запросу

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